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Author

Angelika B. Riemer

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Open access Oct 2026

The Impact of a Short-Term Reduction in CD8+ T Cells on Aged APP/PS1 Mice

CD8⁺ T cells infiltrate the brain parenchyma of patients with Alzheimer’s disease (AD), where they localize near microglia and neurons. Although recent studies have revealed that they can clonally expand and possess a unique phenotype, their contribution to disease pathogenesis remains poorly understood. To investi...

Marco Zattoni, Sabine Bernegger, H. Mrowetz et al. · 0 citations
Open access Aug 2026

A targetable dependency on nonsense-mediated decay for cellular homeostasis and immune control in small cell lung cancer

This work identified that NMD inhibition boosted neoantigen expression and presentation by tumor cells and increased T cell recognition, thus enhancing overall tumor immunogenicity and further improving immunotherapy efficacy in vivo, uncovering a novel TMB-dependent tractable vulnerability for this devastating disease...

Lucia A. Torres-Fernández, V. Boehm, Joel Kaufmann et al. · 0 citations

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