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Open access Aug 2026

A Conserved Flexible N-Terminal Domain Tunes the Calcium Sensitivity of Sorcin by Stabilizing Its Active Conformation

The NTD is established as a critical regulator that enhances Ca2+ responsiveness by shifting Sorcin’s conformational equilibrium toward the active state and suggest that flexible N-terminal extensions regulate signaling within the penta-EF-hand protein family.

Qiushi Ye, Angela Wu, K. Carillo et al. · 0 citations
Open access Aug 2026

Machine Learning-Guided Design of Novel Janus Kinase Inhibitors for Rheumatoid Arthritis Treatment

Focusing on the JAK2 protein, in-silico novel small molecules with higher binding affinity than the existing drugs are identified through a computational screening process that combines the generation of a drug compound library, development of predicative machine learning model, and molecular dynamics-based modeling.

Angela Wu · 0 citations

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