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Angela L. Jefferson

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Open access Oct 2026

Lower cardiac output is associated with longitudinal decreases in cerebrospinal fluid amyloid-β42, a core Alzheimer's disease biomarker, in women but not men.

Subclinical reductions in cardiac output relate to cognitive decline. We examined the relationship between cardiac output and cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease pathologies in 153 participants from the Vanderbilt Memory and Aging Project. Linear regression and linear mixed effects regression mo...

Amalia J. Peterson, Yun-Yi Sun, Dan-Dan Liu et al. · 0 citations
Open access Oct 2026

UPER: A Unified Polyhedral Representation for universal multi-dimensional diffusion MRI image modeling.

Medical computer vision presents unique challenges compared to natural images, largely due to the high dimensionality of the data (e.g., 3D and 4D imaging) and limited training samples. Certain medical imaging modalities, such as Diffusion-weighted Magnetic Resonance Imaging (dMRI) - a critical tool for examining brain...

Tian-Yuan Yao, Zhi-Yuan Li, Michael E. Kim et al. · 0 citations
Review Open access Sep 2026

Development and Preliminary Feasibility Testing of PACERS, a Physical Activity-Centered Intervention for Rural Older Adults With Hypertension.

This study aimed to engage rural community members in designing, developing, and preliminarily testing the feasibility of a physical activity (PA)-centered health promotion intervention integrating Fitbit-based activity monitoring and text messaging among rural older adults (50+ years) with hypertension (PACERS).

Stella T. Lartey, M. Heo, Joel E. Williams et al. · 0 citations
Preprint Sep 2026

Bayesian Variable Selection for High-Dimensional Predictors with Missing Psychometric Outcomes

High-dimensional, multimodal predictors and partially observed multivariate outcomes are common in psychometric research. However, existing regularization methods often do not accommodate hierarchical predictor structures and are primarily designed for univariate outcomes. We propose SHIM, a Bayesian framework for stru...

Zong-Yue Teng, Shu-Jie Ma, T. Hohman et al. · 0 citations
#small language model Open access Sep 2026

Arterial Spin Labeling Hemodynamic Indices Relate to Cognitive and Small Vessel Disease Trajectories Over 11 Years

ASL-sCoV may serve as an important hemodynamic measure for identifying perfusion deficits tied to SVD burden and progression and could provide substantial insight into the longitudinal clinical consequences of SVD.

W. Robb, Ava M. Santner, Pan-Pan Zhang et al. · 0 citations
Open access Jul 2026

A comparative evaluation of multiple enlarged perivascular space segmentation tools.

DORES provides a multimodal nnU-Net-based pipeline for ePVS segmentation in older adults and demonstrates robust within-cohort performance and reasonable external validity, though scanner-related effects limit application across sites.

James D. LeFevre, W. Robb, Dan-Dan Liu et al. · 0 citations

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