Author

Angela J. Russell

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Open access Oct 2026

Phenotypic screening identifies kenpaullone as a prolymphangiogenic compound to improve heart repair following myocardial infarction.

Myocardial infarction (MI) induces cardiac muscle death and its subsequent replacement by a noncontractile fibrotic scar, which underlies progression to heart failure. Current treatments restore blood flow and assist with cardiac workload but do not promote regeneration. We have previously shown endogenous growth of th...

Christophe Ravaud, C. Cuoco, Sarah Sigal et al. · Proceedings of the National... · 0 citations

Open access Sep 2026

Mechanism of GPR84 allosteric modulation at a helix 8–proximate site

Allosteric modulators offer opportunities for pathway-selective G protein–coupled receptor (GPCR) signaling, but the mechanisms enabling biased allosteric modulation remain poorly understood. We identify a helix 8–proximate allosteric site in the immune-metabolic receptor GPR84 and define how it achieves Gi-biased sign...

Xuan Zhang, Abdul-Akim Guseinov, Laura Jenkins et al. · Science Advances · 0 citations

Open access Sep 2026

Steric control of signaling bias in the immunometabolic receptor GPR84

Biased signaling in G protein-coupled receptors offers therapeutic promise, yet rational design of biased ligands remains challenging due to limited mechanistic understanding. Here, we report a molecular basis for controlling signaling bias at the immunometabolic receptor GPR84. We identify three structurally-matched l...

Pin-Qi Wang, Xuan Zhang, Abdul-Akim Guseinov et al. · Nature Communications · 0 citations