Open access
Sep 2026
Human iPSC models reveal APOE4-induced microglial remodeling and extracellular vesicle dysregulation in AD pathogenesis
Abstract The apolipoprotein E ε4 ( APOE4 ) allele is the strongest genetic risk factor for late-onset Alzheimer’s disease (AD), yet the mechanistic underpinnings by which it alters human microglial function remain poorly understood. Here, we utilize CRISPR/Cas9-engineered isogenic human induced pluripotent stem cell-de...
T. Ikezu, Y. You, Son Nguyen et al.
· Research Square · 0 citations