Non-electrophilic TRPA1 modulator MNP-021 protects neuronal and glial function from diabetes-associated glucotoxicity and neuroinflammation
In a sustained high-glucose model, MNP-021 reduced the high-glucose-associated increase in cell death, extending its protective effects beyond the acute MGO paradigm, and support further preclinical evaluation of MNP-021 in dicarbonyl-linked neuro-metabolic stress.
Alessandro De Carli, Carolina Filipponi, Beatrice Polini et al.
· Journal of Translational Med... · 0 citations