Author

Andy W. Dahl

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Open access Oct 2026

Understanding genetic and environmental complexity in phenotypic resemblance across relatedness in population-scale data

A fundamental feature of a trait’s variation in a population is how its phenotypic similarity scales with genetic relatedness. Under a strictly additive model of genetic architecture, phenotypic similarity increases linearly with genetic relatedness, with a slope equal to the heritability; this underpins approaches to...

Mariadaria K. Ianni-Ravn, Andy W. Dahl, John Novembre · bioRxiv · 0 citations

Open access Aug 2026

Locus-specific gene-context interactions improve polygenic prediction

Polygenic scores (PGS) are a primary output of large-scale genetic studies and are being deployed in clinical and non-clinical settings. However, current PGS assume simple additive models that ignore context-specific genetic effects, which likely reduce their accuracy and robustness. To address this, we developed PGSC,...

Renée Fonseca, C. Caggiano, Manuela Costantino et al. · bioRxiv · 1 citation

Open access Aug 2026

Cell-type-specific eQTLs underlie the genetic architecture of complex traits.

This work unbiasedly characterized cell-type-specific eQTLs by applying a variance component model to population-scale single-cell RNA-sequencing (RNA-seq) data and established eQTL cell-type specificity as a key feature of gene regulation and partly explain why known eQTLs are depleted in gene regulatory effects on co...

Minhui Chen, Xin-Pei Wang, Lena Krockenberger et al. · Nature · 1 citation