Author

Andy P. Tsai

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Review Open access Sep 2026

Extracellular Mitochondrial Components as Emerging Biomarkers and Therapeutic Targets in Human Diseases

Mitochondria serve as the bioenergetic hub of eukaryotic cells while simultaneously acting as a major source of cellular stress and toxicity. Classical mitochondrial quality control (MQC) has long been viewed as a lysosome-dependent process centered on mitophagy. However, aging is accompanied by progressive lysosomal d...

Kuan-Hao Tsui, Emmanuel Naveen Raj, Andy P. Tsai et al. · International Journal on Bio... · 0 citations

Review Open access Sep 2026

Clonal Mosaicism of Mitochondrial DNA Heteroplasmy as a Molecular Clock of Aging

Current evidence is synthesized to argue that clonal mosaicism of mtDNA heteroplasmy constitutes a quantifiable, tissue‐specific molecular clock of aging, and the mitochondrial clock is positioned alongside epigenetic and other aging clocks, highlighting concordance, complementarity, and what must be resolved before he...

Renin Chang, Andy P. Tsai, Bo-Yang Wang et al. · Aging Cell · 0 citations