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Andualem Mekonnen Hiruy

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Open access Sep 2026

Spatiotemporal Variation of PM2.5 Concentration and Health Impacts in Addis Ababa, Ethiopia: Trends and Patterns

This study investigated the spatiotemporal variability of fine particulate matter (PM2.5) in Addis Ababa, Ethiopia and assessed its associated health risks and economic burden using data from January 2022 to December 2023. Hourly PM2.5 concentrations were collected through a hybrid monitoring network comprising seven low-cost sensors and two Beta Attenuation Monitors (BAM). Spatiotemporal analysis was performed using Python, and health risks were assessed by estimating the Hazard Quotient (HQ) and Excess Lifetime Cancer Risk (ELCR). The economic burden attributable to PM2.5 exposure was assessed by monetizing disease-specific Disability-Adjusted Life Years (DALYs) using a locally adapted Value of Statistical Life (VSL) approach. Over the two-year periods, mean PM2.5 concentrations ranged from 15 to 33 μg/m3 across monitoring sites, with an overall a citywide average of 27 μg/m3, exceeding the World Health Organization (WHO) Air Quality Guideline (AQG) of 5 μg/m3 by more than fivefold. Seasonal analysis revealed elevated PM2.5 concentrations during the wet season (Kiremt), while diurnal patterns showed peaks of 38 µg/m3 at 7:00 AM. The HQ values for all age groups exceeded the acceptable threshold of 1, indicating non-carcinogenic health risks. ELCR estimates calculated using a slope factor of 0.008 exceeded the risk threshold (1 ×10-4), whereas estimates based on the slope factor of 0.0012 remained within the acceptable limits, highlighting the sensitivity of cancer risk estimates to the toxicity parameter applied. The economic burden attributable to PM2.5 exposure was estimated at USD 652.95 million over the two-year study period, contributing an external cost share to national GDP of 0.25% in 2022 and 0.25% in 2023. Cardiovascular diseases, particularly ischemic heart disease (IHD), accounted for the largest share of economic losses, significantly exceeding acute respiratory infections and PM2.5 related cancers. These findings provide evidence to support targeted policies aimed at reducing PM2.5 related cancers combined.

Andualem Ayele Mengistu, Andualem Mekonnen Hiruy, Eyale Bayable Tegegne · 0 citations
Open access Aug 2026

Comparative Efficacy of Leaf and Root Extracts of Rumex nepalensis Against Multidrug-Resistant Bacterial Pathogens: An in Vitro Study

This study aimed to compare the in vitro antibacterial activity of methanolic and aqueous extracts of Rumex nepalensis leaves and roots against multidrug-resistant bacterial pathogens. Leaves and roots were collected, shade-dried, and extracted with 80% methanol and distilled water. Phytochemical screening, Fourier transform infrared spectrophotometer (FTIR) characterization, agar well diffusion, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) assays were performed against Escherichia coli ( E. coli ), Salmonella typhimurium ( S. typhimurium ), and Staphylococcus aureus (S .aureus ), using ciprofloxacin as the reference drug. Methanolic leaf extracts produced the largest inhibition zones (27.0–28.7 mm against S. aureus and 26.7 mm against E. coli at 125 mg/mL), often matching or exceeding ciprofloxacin. Leaf extracts showed lower MIC values (15.6–31.25 mg/mL) compared with root extracts (31.25–125 mg/mL). MBC values were generally equal to or one dilution higher than the corresponding MIC values. Methanolic leaf extracts of Rumex nepalensis demonstrated markedly superior antibacterial activity against the tested multidrug-resistant strains compared with root extracts and aqueous extracts, supporting the plant’s potential as a natural source of antimicrobial agents.

Addis Mekonnen Woldehana, Tadesse Alemu Terfie, A. A. Dubale et al. · 0 citations

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