Andrey V. Timofeev

Deterministic Finite-Scale Geometry of RNA Language Model Embeddings Predicts siRNA Efficacy: Gϵ(r) Outperforms LID as a Functional Complexity Measure

Motivation. BLAST-based screening of small interfering RNAs (siRNAs) frequently produces false positives in the “grey zone”, where alignment statistics are marginally significant but functional affinity is low. Existing approaches based on local intrinsic dimensionality (LID) of language model embeddings are unstable o...