Author

Andrew Mcpherson

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Open access Sep 2026

MMEJ repair of breaks at TA repeats maintains ecDNA and cancer fitness

Extrachromosomal DNA (ecDNA) comprises megabase-sized circular DNA elements that frequently carry oncogene amplifications, driving aggressive tumour phenotypes, therapeutic resistance and poor clinical outcomes across many cancers1, 2, 3–4. Although ecDNA is thought to arise from canonical double-strand break repair, t...

David Billing, Monica Selvaraj, M. E. Kelley et al. · Nature · 1 citation

Open access Aug 2026

Recurrent non-canonical proteoforms in acute myeloid leukemia identified by integrative proteogenomics

A recurrent AML dark proteome is defined and a framework for the discovery of tumor-specific non-canonical proteins for mechanistic and therapeutic studies is established.

L. Schmalbrock, Asher Preska Steinberg, Katarzyna Kulej et al. · bioRxiv · 0 citations

Open access Aug 2026

A compendium of next-generation patient-derived models for diverse cancers

A large-scale international programme—the Human Cancer Models Initiative—is presented, which involved the generation of a resource of 665 next-generation models from 2,780 donors with 25 cancer types and integrated tumour–model whole genome, exome, methylome and transcriptome analyses.

Dina Elharouni, Mushriq Al-Jazrawe, Seongmin Choi et al. · Nature · 7 citations