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Author

Andrew Highton

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Open access Sep 2026

Targeting epithelial IFN-I signaling restores barrier integrity in anti-TNF refractory Crohn’s disease

It is demonstrated that TNF signaling sustains epithelial IFN-I responses linked to immune regulation and antiviral pathways, establishing a mechanistic connection between chronic TNF signaling and epithelial barrier failure.

Safina Gadeock, Mikayla R. King, D. Polk et al. · 0 citations

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