Open access
Oct 2026
Molecular mechanism of KRAS binding to BRAF and its regulation by the BRAF-specific region
SUMMARY MAPK pathway activation requires recruitment of RAF kinases by GTP-bound RAS through the RAS-binding domain (RBD) and cysteine-rich domain (CRD). BRAF uniquely contains an N-terminal BRAF-specific region (BSR), but the structural basis of KRAS engagement and BSR function remain unclear. Here, we report the stru...
D. Bonsor, Suzanne I. Sandin Lawrence, Timothy H. Tran et al.
· Structure · 0 citations