Andreea Larisa Mateias

Molecular basis for a Ca2+ binding hierarchy in the EF-hand motifs of CaBP2.

Calcium binding protein 2 (CaBP2), a member of the calmodulin (CaM) superfamily, modulates the L-type calcium channel CaV1.3 in the cochlear inner hair cells by suppressing its voltage- and Ca2+-dependent inactivation. Like CaM, CaBP2 contains four EF-hand motifs, although only three are functional, yet the precise nat...