Open access
Oct 2026
Chronic XBP1s-mediated activation of the unfolded protein response impairs CD8+ T cell anti-tumor immunity
CD8 + T cells play a crucial role in anti-tumor immunity; however, their functionality is compromised by exhaustion driven by chronic antigen exposure, poor tumor microenvironment, and metabolic dysfunction. Activated CD8 + T cells undergo extensive proteomic remodeling, which includes the induction of the IRE1-X...
Keith A. Nair, Jessica Lee, Olivia Zaleski et al.
· Frontiers in Immunology · 0 citations