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Csnk1a1 E98 mutations rewire signaling and metabolism in del(5q) myelodysplastic neoplasms.
Deletion of chromosome 5q [del(5q)] is the most common cytogenetic abnormality in myelodysplastic neoplasms (MDS) and results in haploinsufficiency of multiple genes, including CSNK1A1. Recurrent CSNK1A1 mutations, predominantly affecting the E98 hotspot, occur almost exclusively in del(5q) MDS and are associated with...
Mechanisms underlying propagation of ferroptotic cell death
Emerging evidence for non-cell-autonomous propagation of ferroptotic cell death is discussed and the mechanisms that underlie its restriction in tissues are highlighted, as well as ferroptosis surveillance beyond the cellular level.