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Andrea Roncoli

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Open access Sep 2026

MIMOSA: Guiding De Novo Antibody Design with Natural Interaction Fingerprints

De novo antibody design promises to transform therapeutic antibody and nanobody discovery. Yet, success remains inconsistent across targets, with generative models often yielding no experimentally validated binders. Here we introduce MIMOSA (MIMic-Oriented Structural Antibody generation), a model-agnostic, inference-ti...

Brennan Abanades, Andrea Roncoli, Maniraj Bhagawati et al. · 0 citations

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