Open access
Sep 2026
CHD8 orchestrates chromatin landscapes during early female neuronal differentiation
Background Autism spectrum disorder (ASD) shows a strong male bias (∼4:1). CHD8, a frequently mutated ASD gene, regulates neuronal development and Xist regulation in X-chromosome inactivation (XCI). However, its role in female neurodevelopment remains poorly understood due to the predominance of male-derived or sex-agn...
Ajay Kumar Danga, Alessio Colantoni, Nicola Pomella et al.
· bioRxiv · 0 citations