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Andrea Catte

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Open access Oct 2026

A combined computational and experimental study of the interaction between the voltage-gated potassium channel Kv4.3 and its auxiliary protein KChIP

Voltage-gated potassium (Kv) channels of the Kv4 subfamily are central regulators of neuronal and cardiac excitability. In particular, Kv4.3 plays a vital role in shaping the timing, frequency, and backpropagation of electrical signals in the brain and heart by generating fast transient currents at subthreshold membran...

Luca Benedetti, S. Biswas, L. Ferbel et al. · 0 citations
Open access Sep 2026

Structure- and Dynamics-Driven Discovery of Small Molecule Inhibitors Targeting a Conserved Pocket near the Fusion Peptide in the Prefusion SARS-CoV‑2 S2 Glycoprotein Subunit

A structure- and dynamics-driven virtual screening to identify novel small-molecule inhibitors of SARS-CoV-2 cell entry by targeting a conserved pocket within the S2 subunit of the spike glycoprotein domain showed good conservation of the pharmacophore region among different SARS-related coronaviruses.

M. Leusciatti, S. Rinaldi, R. Arvia et al. · 0 citations

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