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Author

Ancha Baranova

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Open access Oct 2026

Antidepressant use and Parkinson's disease risk: Overall protective effect with drug‐specific variation

ABSTRACT Background Antidepressants can cause extrapyramidal side effects, but their impact on Parkinson's disease (PD) risk remains unclear. Aims We aimed to investigate the association between genetic liability to antidepressant use and PD. Methods We examined the causal effect of antidepressant use on PD using Mende...

Ancha Baranova, Hong-Bao Cao, Chen-Xin Xu et al. · 0 citations
Open access Oct 2026

Causal associations between gut microbiota and autism spectrum disorder and attention-deficit/hyperactivity disorder: a two-sample mendelian randomization study

The gut microbiota have been implicated in the development of autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD). However, the precise causal relationships between the gut microbiota and ASD or ADHD remain unclear. We investigated potential causal associations between gut micr...

S. Shi, Ancha Baranova, Hong-Bao Cao et al. · 0 citations
Sep 2026

Evaluating the causal effects of circulating metabolites on major depression disorder.

Genetically proxied circulating metabolites showed reproducible associations with MDD, while reverse effects were supported by only two metabolic traits, which may help prioritization of candidate biomarkers for risk stratification in patient cohorts and generate hypotheses for mechanistic research.

Jian-Bin Du, Ancha Baranova, Hong-Bao Cao et al. · 0 citations
Review Jul 2026

Neuroimmune lipidome dysregulation in major depressive disorder: A meta-analysis of peripheral endocannabinoid and n-acylethanolamine signaling.

Circulating lipid signaling molecules such as AEA and PEA may represent potential peripheral biomarkers of MDD, although longitudinal and mechanistic studies are needed to clarify the influence of treatment and comorbidities.

Muhammad Yaseen, Wei-Jen Chen, Jane-Pei-Chen Chang et al. · 1 citation
Jul 2026

Exploring the Causal Role of Circulating Inflammatory Proteins in Multiple Sclerosis: A Mendelian Randomization Study and Druggability Analysis.

Genetic evidence linking inflammatory proteins to MS pathogenesis was uncovered, offering clues for novel therapeutic targets for this condition and strengthening the biological plausibility of inflammation-driven disease mechanisms.

Run-Yang Xu, Ancha Baranova, Hong-Bao Cao et al. · 0 citations
Aug 2026

Association between antidepressant use and the risk of type 2 diabetes: a multi-stage Mendelian randomization study.

Genetic evidence suggesting medication-specific associations between antidepressant use liability and T2D susceptibility is provided, highlighting that the metabolic effects of individual antidepressants may vary, thus, warranting further studies to determine the clinical relevance of the findings.

Dongming Liu, Ancha Baranova, Chenxin Xu et al. · 0 citations

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