Open access
Sep 2026
Functional annotation of insulin-responsive genes in human adipocytes reveals PLCXD1 as a lipid storage regulator
The results uncover PLCXD1 as an insulin-regulated enzyme linking endosomal phosphoinositide metabolism to lipid storage in adipocytes, and show that PLCXD1 catalytic activity is required for insulin-stimulated lipogenesis.
Scott Frendo-Cumbo, Danae Zareifi, Joëlle Bigay et al.
· Nature Communications · 1 citation