Remodeling of lipid metabolism orchestrates human adipose-derived mesenchymal stem cells osteodifferentiation.
A global metabolomics approach is used, comprising LC-MS lipidomics and NMR metabotolomics, to identify mechanistic features of human adipose-derived MSC (hAMSC) osteodifferentiation and new markers of osteogenic progression, enabling actionable monitoring and rational optimization of bone tissue engineering strategies...