Ana Aragón-González

α-Synuclein blocks endoplasmic reticulum co-translational protein translocation early in Parkinson’s disease

The primary mechanism and subcellular localisation of α-synuclein toxicity in Parkinson’s disease pathogenesis remain unknown. We spatially and temporally resolved proteomic and transcriptomic changes in human iPSC-derived dopaminergic neurons with increasing burden of pathological α-synuclein. We found that misfolded...