Author

An-Nan Liu

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Review Sep 2026

Mitochondria-Endoplasmic Reticulum Contact Sites (MERCS/MAM): Multi-Layered Upstream Regulators of Microglial Senescence in Alzheimer's Disease.

Overall, MERCS dysfunction is proposed as a candidate multimodal upstream hub for calcium, mitochondrial, inflammatory, lipid and ER-stress signalling, and rigorous in-vivo validation together with microglia-selective delivery platforms is essential for therapeutic translation.

An-Nan Liu, Li-Ping Xing, Jian-Hui Li et al. · Ageing Research Reviews · 0 citations

Review Open access Aug 2026

Mitochondrial dysfunction-driven ferroptosis in cerebral ischemia-reperfusion injury: Mechanisms and therapeutic strategies (Review)

A multidimensional pathological network composed of multiple mitochondrial abnormalities, including mitochondrial reactive oxygen species bursts, Ca2+ overload and disruption of the mitochondrial quality control system, synergistically amplifies lipid peroxidation and drives neuronal ferroptosis across the pathophysiol...

Jian-Hui Li, An-Nan Liu, Wei Gao et al. · Molecular Medicine Reports · 0 citations