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#protein folding Oct 2026

Charge-altering histone mutations reprogram electrostatic coupling from single nucleosomes to higher-order chromatin structures.

It is shown that charge-altering mutations are enriched among recurrent high-frequency mutations and exhibit stronger predicted destabilizing effects on nucleosome-associated interactions than charge-neutral variants, and higher-order nucleosome assemblies show that charge-altering mutations can modulate inter-nucleoso...

Hou-Fang Zhang, Guan-Hua Hu, Ge-Ge Liu et al. · 0 citations
Open access Jul 2026

Computational Characterization of Multistep Opening Mechanism and Heterogeneous Closing Pathways of Periplasmic Binding protein Ps_PtxB

The results suggest that Ps_PtxB opening proceeds through a multistep process involving early Lobe1-Lobe2 interface decoupling, hinge-associated stabilization, twisting rearrangement, and subsequent coordinated domain motion and suggest that molecular simulation-derived dynamic information can guide interpretable confo...

He Feng, Chen Zeng, Long Chen et al. · 0 citations

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