Review
Open access
Jul 2026
From Selfish Transposon Enzymes to Programmable Miniature Genome Editors: The Biology, Evolution, and Engineering of TnpB Nucleases
The principal challenges, including transposon-associated motif (TAM) restriction, off-target activity, delivery and mechanistic understanding, that must be addressed are outlined before the therapeutic and agricultural potential of TnpB-derived technologies can be fully realised.
Sanchit Pal Singh, Shruti Gupta, Rohit Solanki et al.
· Journal of Advances in Biolo... · 0 citations