Author

Amr Ali Mohamed Abdelgawwad El-Sehrawy

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Review Sep 2026

SLC7A11 in liver tissue homeostasis and disease: Cellular mechanisms linking ferroptosis, redox regulation, and hepatic cell survival.

Liver diseases involve major disturbances in iron metabolism, redox homeostasis, and lipid peroxidation; therefore, ferroptosis is considered as an important link between cellular stress and liver damage/progression. This article describes solute carrier family 7 member 11 (SLC7A11), the functional subunit of the cysti...

J. Gupta, Musaab Hamid Farhan, A. Smerat et al. · Tissue & Cell · 0 citations

Review Open access Aug 2026

Epigenetic Rewiring and Context‐Dependent Therapeutic Vulnerabilities in Myeloproliferative Neoplasms

Myeloproliferative neoplasms (MPN) are shaped by epigenetic rewiring that extends beyond canonical JAK2V617F‐driven signaling. This review argues that context‐dependent chromatin states, not merely genetic lesions, determine disease trajectory, fibrotic transformation, and leukemic progression. We synthesize recent evi...

Amr Ali Mohamed Abdelgawwad El-Sehrawy, M. Al-Khreisat, Aziz Kubaev et al. · Hematological Oncology · 0 citations

Review Open access Aug 2026

Exosome-mediated siRNA delivery in cancer: Loading strategies, targeting approaches, and therapeutic outcomes

Challenges such as scalable production, cargo heterogeneity, and regulatory considerations remain, but ongoing advances in exosome engineering and patient-derived vesicles are poised to overcome these barriers.

Amr Ali Mohamed Abdelgawwad El-Sehrawy, Hassan Youssef Hussein, O. Nematov et al. · DARU Journal of Pharmaceutic... · 0 citations