Development and Validation of a High-Performance Liquid Chromatography (HPLC) Method for the Quantitative Determination of Caffeine in Rat Plasma for In Vivo Bioanalysis
Caffeine is one of the most widely consumed methylxanthine compounds and is rapidly absorbed into the bloodstream following oral administration. Quantitative analysis of caffeine in biological matrices requires a selective and validated analytical method because blood plasma contains numerous endogenous compounds that...