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Author

Amanda R. Kirane

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2 papers indexed here

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Sep 2026

Predicting Targeted and Immunotherapeutic Response Outcomes in Melanoma With Single-Cell Raman Spectroscopy and Artificial Intelligence.

This work presents a nondestructive, single-cell approach combining Raman spectroscopy and machine learning that enables rapid cell profiling and therapeutic response prediction and may improve first- and second-line therapy selection assessments for precision medicine.

Kai Chang, Mamatha Serasanambati, Baba Ogunlade et al. · 0 citations
Open access Jul 2026

AXL tyrosine kinase inhibition restores anti-PD-1 efficacy in melanoma through tumor-associated macrophage—dependent mechanisms 2255689

Immune checkpoint blockade (ICB) has transformed melanoma care, yet resistance is common and often driven by tumor-associated macrophages (TAMs). AXL, a Gas6-activated tyrosine kinase, is classically a tumor-intrinsic driver of invasion but is predominantly expressed by TAMs in melanoma, suggesting a role in regu...

Amanda R. Kirane, David Lee, Saurabh Sharma et al. · 0 citations

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