Author

Amanda Poissonnier

3 papers indexed here

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Sep 2026

Abstract B097: Plectin promotes an aggressive phenotype and represses anti-tumor immunity in pancreatic cancer

Pancreatic adenocarcinoma (PDAC) is an abysmal disease, with a poor clinical outcome, largely due to limited life-extending treatments for patients. Notoriously, PDAC displays a T cell-suppressive tumor microenvironment where underlying molecular mechanisms that lead to this phenotype remain poorly understood. To unr...

Kimberly A. Kelly, Cody L. Wolf, Roxanne K. Ruiz et al. · Cancer Research · 0 citations

Open access Aug 2026

Immune Circuit Rewiring by HDAC Inhibition Enables Response to Dual Checkpoint Blockade in Metastatic Breast Cancer

Overall, this study identifies lymphoid and myeloid cell contributions to response to treatment with HDAC inhibitors and immune checkpoint blockade, providing a framework for discovering interactions driving responses in complex TMEs.

E. Gonzalez, J. Kreger, Ying-Tong Liu et al. · Cancer Research · 0 citations

Open access Aug 2026

Plectin promotes an aggressive phenotype and represses cytotoxic T cell activity in pancreatic cancer

Plectin is identified as a biomarker of aggressive disease in PDAC, with high plectin expression associated with decreased T cell infiltration, and anti-CSP treatment reinstates antitumor immunity and decreases tumor volume in vivo.

Cody L. Wolf, Roxanne K. Ruiz, Sokchea Khou et al. · Frontiers in Immunology · 0 citations