Open access
Sep 2026
Inositol Hexakisphosphate Promotes Open Pore State in HIV Capsid Protein Lattice by Reconfiguring Subunit Contacts
IP6 is established as a proviral regulator that couples nanoscale pore dynamics, intersubunit contact reconfiguration, and mechanical resilience of the HIV-1 capsid, providing a unified mechanistic framework for its role in viral replication.
Y. Knelissen, Judith Escrig, Amanda C. Macke et al.
· ACS Nano · 0 citations