Amaia Alday-Izaguirre

Epitope-imprinted nanoparticles prepared by controlled solid-phase synthesis for low-nanomolar-affinity SARS-CoV-2 spike recognition and direct non-faradaic impedance sensing in oral fluid.

Herein we present molecularly imprinted nanoparticles (MIN) as synthetic antibodies with nanomolar affinity (4.57 ± 0.01 nM) targeting the spike protein of the SARS-CoV-2. The peptide corresponding to the residues 470-TEIYQAGST-478 was selected as the template to produce nanoparticles via solid-phase epitope imprinting...