Alyaa Dawoud

Extracellular Matrix Remodeling in Tumors: Forces Beyond Fibroblasts.

Aberrant extracellular matrix (ECM) remodeling in tumors is characterized by altered deposition, enzymatic cross-linking, degradation, and organization of matrix molecules that in turn can contribute directly to tumor invasiveness, immune evasion, and resistance to therapy. Traditionally, cancer-associated fibroblasts...