Alper Karagöl

The Apolipoprotein E N-Terminal Bundle Rendered Membrane-Compatible by Reverse-QTY Conversion Without Loss of Fold

Apolipoprotein E (ApoE) performs most of its pathologically relevant biology at lipid interfaces, yet design efforts target its receptor binding, interdomain geometry or abundance rather than the lipid affinity of its N-terminal bundle. We asked whether the reverse-QTY (rQTY) code can make that bundle membrane-compatib...

In silico directed evolution of humanized peptide transporters via computational epistatic rescue.