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Allen Lobo

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Open access Aug 2026

Thermodynamic Profiling of Glucose Translocation in POPC embedded GLUT-4 protein models

A comparative biophysical analysis of glucose translocation using both the native Cryo-EM structure and the AI-predicted AlphaFold model is conducted, establishing that rigid AI-generated architectures lack the essential internal free volume and conformational plasticity required to sustain accurate thermodynamic profiling of dynamic membrane transporters.

S. Govinda, Suhotra Das, Allen Lobo et al. · 0 citations

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