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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Alison F. Munro

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Open access Oct 2026

SMAD3-driven cell state transitions underpin immunoresistance in bladder cancer

Despite the clinical success of anti-PD-1/PD-L1 immunotherapy in a subset of patients with high-risk bladder cancer (BLCA), most tumors remain refractory to treatment. We hypothesized that immunotherapy resistance is encoded within the intrinsic signaling state of BLCA cells and arises through specific cell-state trans...

Sarah Y. T. Robertson, J. Yang, Neil O. Carragher et al. · 0 citations

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