Open access
Oct 2026
Cell-type-specific repression reveals MC4R neurons as a site of action for ciliary obesity genes.
OBJECTIVES Understanding how obesity-associated genes function within defined neuronal subpopulations remains a major barrier to translating human genetics into pathophysiological mechanisms. Melanocortin-4 receptor-expressing (MC4R) neurons are key regulators of energy homeostasis and represent a potential site of act...
Abbey Diener Blake, Zhi-Xuan Zhang, Coralie Alexandre et al.
· Molecular Metabolism · 0 citations