Author

Alice Mayer

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Open access Sep 2026

Cell-type specific analyses in blood and gut identify cis-eQTL matching 140 IBD risk loci and entrectinib as repurposing candidate

Genes whose expression is affected, in a consistent manner, by GWAS-identified risk variants and the disease process, constitute preferred drug targets. We herein combine cis-eQTL analysis in 27 sorted blood cell populations and 43 intestinal cell types identified by single cell RNA-Seq in the ileum, colon and rectum,...

H. Perée, Viacheslav A. Petrov, Y. Tokunaga et al. · Nature Communications · 0 citations

Review Open access Aug 2026

Loss of cellular RNA homeostasis contributes to MDA5 activation during virus infection

This work shows that MDA5 binds aberrant host RNA induced during viral infection, and proposes that MDA5 surveys RNA processing fidelity and can detect infections by sensing perturbations of post-transcriptional events such as splicing.

Natália G. Sampaio, Tanja Davis, L. Gearing et al. · Nature Immunology · 1 citation