Ali Necmi Eren

Immune profiling of anti-SSA–positive at-risk individuals reveals increased type I IFN activity preceding lymphocyte abnormalities in Sjögren’s disease

The data suggest that increased type I IFN activity and IFN-associated signaling in T- and B-cell subsets are already present in anti-SSA–positive at-risk individuals, indicating progression from autoreactivity toward overt autoimmune disease.