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Open access Oct 2026

Targeting NOTCH-immune crosstalk in gliomas: from mechanisms to therapeutics

Glioblastoma (GBM) is a highly aggressive and treatment-resistant malignancy characterized by an immunosuppressive tumor microenvironment (TME) that promotes disease progression and poor clinical outcomes. Increasing evidence suggests that NOTCH signaling is a key regulator of GBM progression, governing both tumor cell...

Safieh Ebrahimi, N. Meshkinkhood, Ali Aliee et al. · 0 citations
Review 2026

Biological roles and clinical potential of piRNAs in cancer: Insights into glioblastoma

Non-coding RNAs serve as key regulators of gene expression at both the transcriptional and post-transcriptional levels. Among them, piRNAs, a class of small non-coding RNAs, have emerged as significant mediators in cancer biology. PIWI proteins, members of the Argonaute family highly expressed in germline cells, intera...

A. Nakhaei, A. Omidkhoda, Farzaneh Abbasinezhad-Moud et al. · 0 citations

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