Open access
Sep 2026
Developmental xenocortication using human-derived organoids in mice
This platform establishes a transplantation platform using a genetic strategy to effectively deplete glutamatergic neurons from mouse neocortex and hippocampus and neonatally engraft the cortical cavity with human stem-cell-derived cortical organoids (hCO) to generate xenocortical mice, and envision that xenocorticatio...
Konstantin Kaganovsky, Kevin W. Kelley, T. Gschwind et al.
· Nature · 5 citations