Review
Open access
Jul 2026
Functional interplay between TTP/ZFP36 and HuR/ELAVL1 in cancer: a post-transcriptional regulatory network
This review summarizes current knowledge regarding the molecular biology of TTP and HuR, emphasizing their opposing functions in mRNA metabolism and cancer progression; discusses mechanisms regulating their expression, localization, phosphorylation, and RNA-binding activity; analyze cancer-specific evidence; and examines models in which both proteins are co-expressed or functionally interconnected.
R. Lotti, Tommaso Selmi, Alexis Grande et al.
· Frontiers in Oncology · 0 citations