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Author

Alexei Pushechnikov

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2 papers indexed here

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#protein folding Oct 2026

Temporally Validated Models for Target “Tclin-likeness”

Identifying which human proteins are likely to become validated drug targets remains a challenge in drug discovery. We build on the “Tclin” concept, which encompasses proteins for which at least one approved drug exerts its mode of action (MoA); these comprise only ∼3% of the human proteome. We developed disease-agno...

Mohammed Quazi, Suman Sirimulla, Cristian G. Bologa et al. · 0 citations
Review Sep 2026

The evolving landscape of drug targets.

This Review map and quantify key elements of changes in the number and type of targets through which drugs mediate their therapeutic effects, which now include 686 biomolecules modulated by 1,702 drugs.

L. Halip, Sorin Avram, John P. Overington et al. · 0 citations

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