Author

Alexandre Vallée

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Open access Aug 2026

From digital twins to clinically trustworthy twins: a clinical-claim-based validation framework for personalized digital health

It is argued that the next bottleneck for digital twins in health is not model complexity but clinical trustworthiness, and validation should integrate verification, calibration, external and temporal validation, uncertainty quantification, fairness assessment, target trial emulation where causal claims are made, and p...

Alexandre Vallée · Frontiers in Digital Health · 0 citations

Review Open access Aug 2026

Validating medical digital twins for clinical decision support: beyond predictive accuracy

Intervention-oriented digital twins address action-conditioned questions: what is predicted to happen under specified alternative actions, assumptions, time horizons, and clinical contexts and their validation should extend beyond scalar performance metrics to include uncertainty representation.

Alexandre Vallée · JAMIA Open · 0 citations