Hyperglycemia-induced metabolic rewiring is associated with skeletal muscle loss in a fructose-streptozotocin-induced diabetic rat model.
AIMS This study investigated the impact of hyperglycemia on systemic and skeletal muscle metabolite profiles. METHODS Serum and gastrocnemius metabolites of fructose-fed, streptozotocin-injected rats (T2D) were analyzed by 1H NMR and related to markers of energy metabolism and mitochondrial remodeling. RESULTS T2D...