Open access
Sep 2026
Temporal N-terminomics analysis reveals proteome remodeling following brensocatib-mediated cathepsin C inhibition in promyeloblast cells
Cathepsin C (CatC) is known to activate neutrophil serine proteases (NSPs) involved in innate immune function, although its broader impact on cellular proteolytic networks remains poorly defined. Here, we characterized the proteolytic landscape of HL-60 neutrophil progenitor cells following treatment with the CatC inhi...
Yi-Min Zhu, Stephan Luedtke, Bang-Yan Xu et al.
· bioRxiv · 0 citations