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Alexander Kröning

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Open access Oct 2026

Structural dynamics of substrate processing by the p97-Ufd1-Npl4-FAF1 machinery

The AAA-ATPase VCP/p97 unfolds ubiquitylated proteins in key signaling and cellular homeostasis pathways, yet the mechanisms by which Ufd1-Npl4 and FAF1 adapters handle ubiquitin chains to coordinate substrate loading and processing remain unclear. Our cryo-EM study of p97-Ufd1-Npl4 and FAF1 engaging a substrate reveal...

Athina Drakonaki, J. van den Boom, Alexander Kröning et al. · 0 citations

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