Author

Alexander K. Kozlov

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Open access Sep 2026

Surrogate Gradients for Gradient-Based Parameter Estimation in Simplified Neuron Models

Simplified spiking neuron models such as the Adaptive Exponential Integrate-and-Fire (AdEx) model reproduce the firing behaviour of diverse neuron types at a fraction of the cost of biophysically detailed models, making them attractive for large-scale brain simulation. Fitting their parameters to recordings, however, s...

Paul Mayer, Alexander Kozlov · bioRxiv · 0 citations

Open access Aug 2026

Corticostriatal glutamate mechanisms underlying beta synchrony and motor deficits via striatal NMDA receptors in Parkinson’s disease

Summary Background Beta-band (13–30 Hz) oscillations in the cortico-basal ganglia-thalamic (CBT) network strongly correlate with motor deficits in Parkinson’s disease (PD), yet their synaptic origins remain unclear. Given that dopamine (DA) loss is necessary but not sufficient to produce sustained beta rhythms, we hypo...

Zirui Wang, Xinyue Fan, Yuting Zhao et al. · EBioMedicine · 0 citations