Author

Alexander Hoffmann

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#artificial intelligence Review Sep 2026

BioEVAL: A global, multi-institutional benchmark of large language and multimodal models for bioengineering

Large Language Models (LLMs) have demonstrated historic breakthroughs in general reasoning with early successes in biomedical science. However, existing LLM benchmarking emphasizes factual recall, offering limited insight into model performance on frontier and multimodal tasks. We assembled BioEVAL (BioEngineering Vali...

Shun Ye, V. C. Suja, Chen-Long Li et al. · 0 citations

Open access Jul 2026

NF-κB/RelA signaling required for CD40-induced humoral immunity depends on specific NEMO lysine residues in mice

Oxidative stress and genotoxic damage activate NF-κB signaling through intracellular pathways distinct from those initiated by membrane receptors. DNA damage selectively induces post-translational modifications at lysine residues 277 and 309 of the human ubiquitin-binding protein NEMO to promote NF-κB signaling, but th...

Donna Li, S. Wuerzberger-Davis, Yu-Hong Chen et al. · EMBO Journal · 0 citations

Open access Aug 2026

SARS-CoV-2 nucleocapsid induces hyperinflammation and vascular leakage through the Toll-like receptor signaling axis in macrophages

A substantial proportion of hospitalized COVID-19 patients require ICU admission, often associated with an imbalance between antiviral responses and inflammatory signaling leading to uncontrolled cytokine secretion. The SARS-CoV-2 nucleocapsid (N) protein is a known immune antagonist, but its role in macrophage-driven...

Zhen-Lan Yao, Pablo A. Alvarez, Carolina Chavez et al. · Science Advances · 0 citations