Open access
Sep 2026
A positively selected microRNA controls a reversible aging program in striated muscle
It is shown that antisense oligonucleotide-mediated inhibition of miR-128-3p restores muscle mass and function in aged mice, improves cardiac function while limiting adverse remodeling following myocardial infarction, and ameliorates skeletal and cardiac muscle pathology in mouse and pig models of Duchenne muscular dys...
Melissa A. Boldridge, Lei Xu, Xiao-Yin Wang et al.
· bioRxiv · 0 citations